Publications
Preprints
CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development
Xiangling Meng, David Yao, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Shravanti Kulkarni, Michael C. Bassik, Sergiu P. Pașca
bioRxiv 2022 Sept 6. doi: 10.1101/2022.09.06.506845
Xiangling Meng, David Yao, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Shravanti Kulkarni, Michael C. Bassik, Sergiu P. Pașca
bioRxiv 2022 Sept 6. doi: 10.1101/2022.09.06.506845
A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder
Rebecca J. Levy, Katherine W. Timothy, Jack F. G. Underwood, Jeremy Hall, Jonathan A. Bernstein, Sergiu P. Paşca
bioRxiv 2022 Jun 23. doi: 10.1101/2022.06.22.22276784
Rebecca J. Levy, Katherine W. Timothy, Jack F. G. Underwood, Jeremy Hall, Jonathan A. Bernstein, Sergiu P. Paşca
bioRxiv 2022 Jun 23. doi: 10.1101/2022.06.22.22276784
Biocompatible polymers for scalable production of human neural organoids
Genta Narazaki, Yuki Miura, Sergey D. Pavlov, Mayuri Vijay Thete, Julien G. Roth, Sungchul Shin, Sarah C. Heilshorn, Sergiu P. Pașca
bioRxiv 2022 May 17. doi: 10.1101/2022.03.18.484949
Genta Narazaki, Yuki Miura, Sergey D. Pavlov, Mayuri Vijay Thete, Julien G. Roth, Sungchul Shin, Sarah C. Heilshorn, Sergiu P. Pașca
bioRxiv 2022 May 17. doi: 10.1101/2022.03.18.484949
Landscape of human spinal cord cell type diversity at midgestation
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Neal D. Amin, Se-Jin Yoon, William J. Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu Pașca
bioRxiv 2021 Dec 29. doi: 10.1101/2021.12.29.473693
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Neal D. Amin, Se-Jin Yoon, William J. Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu Pașca
bioRxiv 2021 Dec 29. doi: 10.1101/2021.12.29.473693
Peer-reviewed papers
2022
Maturation and circuit integration of transplanted human cortical organoids
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth & Sergiu P. Pașca
Nature. 2022 Oct 13; 610:319–326. doi: 10.1038/s41586-022-05277-w
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth & Sergiu P. Pașca
Nature. 2022 Oct 13; 610:319–326. doi: 10.1038/s41586-022-05277-w
Mouse embryo models built from stem cells take shape in a dish
Neal D Amin, Sergiu P Pașca
Nature. 2022 Oct 3; 610:39–40. doi: 10.1038/d41586-022-03075-y
Neal D Amin, Sergiu P Pașca
Nature. 2022 Oct 3; 610:39–40. doi: 10.1038/d41586-022-03075-y
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
Thomas L. Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P. Paşca
Biomaterials. 2022 Sept 30. doi: 10.1101/2022.06.10.495715
BioRxiv
Thomas L. Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P. Paşca
Biomaterials. 2022 Sept 30. doi: 10.1101/2022.06.10.495715
BioRxiv
Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model
Ren Song, Katja Pekrun, Themasap A. Khan, Feijie Zhang, Sergiu P. Paşca, Mark A. Kay
Molecular Therapy Methods & Clinical Development. 2022 Dec 8; Vol 27:73–88. doi: 10.1016/j.omtm.2022.09.002
Ren Song, Katja Pekrun, Themasap A. Khan, Feijie Zhang, Sergiu P. Paşca, Mark A. Kay
Molecular Therapy Methods & Clinical Development. 2022 Dec 8; Vol 27:73–88. doi: 10.1016/j.omtm.2022.09.002
A nomenclature consensus for nervous system organoids and assembloids
Sergiu P. Pașca, Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, Arnold R. Kriegstein, Madeline A. Lancaster, Guo-Li Ming, Alysson R. Muotri, In-Hyun Park, Orly Reiner, Hongjun Song, Lorenz Studer, Sally Temple, Giuseppe Testa, Barbara Treutlein, Flora M. Vaccarino
Nature. 2022 Sept 29; 609:907–910. doi: 10.1038/s41586-022-05219-6
Sergiu P. Pașca, Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, Arnold R. Kriegstein, Madeline A. Lancaster, Guo-Li Ming, Alysson R. Muotri, In-Hyun Park, Orly Reiner, Hongjun Song, Lorenz Studer, Sally Temple, Giuseppe Testa, Barbara Treutlein, Flora M. Vaccarino
Nature. 2022 Sept 29; 609:907–910. doi: 10.1038/s41586-022-05219-6
Imaging neuronal migration and network activity in human forebrain assembloids
Fikri Birey and Sergiu P. Pașca
STAR Protocols. 2022 Jun 17. doi: 10.1016/j.xpro.2022.101478
Fikri Birey and Sergiu P. Pașca
STAR Protocols. 2022 Jun 17. doi: 10.1016/j.xpro.2022.101478
A tissue-like neurotransmitter sensor for the brain and gut
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B-H Tok, James C Y Dunn, Bianxiao Cui, Sergiu P Pașca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Nature. 2022 Jun; 606(7912):94-101. doi: 10.1038/s41586-022-04615-2
Free PMC article
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B-H Tok, James C Y Dunn, Bianxiao Cui, Sergiu P Pașca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Nature. 2022 Jun; 606(7912):94-101. doi: 10.1038/s41586-022-04615-2
Free PMC article
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.
Birey F, Li MY, Gordon A, Thete MV, Valencia AM, Revah O, Paşca AM, Geschwind DH, Paşca SP. Cell Stem Cell. 2022 Feb 3; 29(2):248-264.e7. doi: 10.1016/j.stem.2021.11.011 BioRxiv |
Chromatin dynamics in human brain development and disease.
Valencia AM, Pașca SP.
Trends in Cell Biology. 2022 Feb; 32(2):98-101. doi: 10.1016/j.tcb.2021.09.001
Valencia AM, Pașca SP.
Trends in Cell Biology. 2022 Feb; 32(2):98-101. doi: 10.1016/j.tcb.2021.09.001
Engineering brain assembloids to interrogate human neural circuits.
Miura Y, Li MY, Revah O, Yoon SJ, Narazaki G, Pașca SP. Nature Protocols. 2022 Jan; 17(1):15-35. doi: 10.1038/s41596-021-00632-z |
A matter of space and time: Emerging roles of disease-associated proteins in neural development.
Panagiotakos G, Pasca SP. Neuron. 2022 Jan 19; 110(2):195-208. doi: 10.1016/j.neuron.2021.10.035 |
Human brain organogenesis: Toward a cellular understanding of development and disease.
Kelley KW, Pașca SP. Cell. 2022 Jan 6;185(1):42-61. doi: 10.1016/j.cell.2021.10.003 |
2021
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.
Science Translational Medicine. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.
Science Translational Medicine. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919.
Nanotechnology Enables Novel Modalities for Neuromodulation.
Yang X, McGlynn E, Das R, Paşca SP, Cui B, Heidari H.
Advanced Materials. 2021 Dec;33(52):e2103208. doi: 10.1002/adma.202103208.
Yang X, McGlynn E, Das R, Paşca SP, Cui B, Heidari H.
Advanced Materials. 2021 Dec;33(52):e2103208. doi: 10.1002/adma.202103208.
Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.
Trevino AE, Müller F, Andersen J, Sundaram L, Kathiria A, Shcherbina A, Farh K, Chang HY, Pașca AM, Kundaje A, Pașca SP, Greenleaf WJ. Cell. 2021 Sep 16;184(19):5053-5069.e23. doi: 10.1016/j.cell.2021.07.039. BioRxiv |
Advancing models of neural development with biomaterials.
Roth JG, Huang MS, Li TL, Feig VR, Jiang Y, Cui B, Greely HT, Bao Z, Paşca SP, Heilshorn SC.
Nature Reviews Neuroscience. 2021 Oct;22(10):593-615. doi: 10.1038/s41583-021-00496-y.
Roth JG, Huang MS, Li TL, Feig VR, Jiang Y, Cui B, Greely HT, Bao Z, Paşca SP, Heilshorn SC.
Nature Reviews Neuroscience. 2021 Oct;22(10):593-615. doi: 10.1038/s41583-021-00496-y.
Mapping human brain organoids on a spatial atlas.
Miura Y, Pașca SP.
Cell Stem Cell. 2021 Jun 3;28(6):983-984. doi: 10.1016/j.stem.2021.05.004.
Miura Y, Pașca SP.
Cell Stem Cell. 2021 Jun 3;28(6):983-984. doi: 10.1016/j.stem.2021.05.004.
Scrutinizing disease states and regulation in human microglia.
Kelley KW, Pașca SP.
Nature Genetics. 2021 Jun;53(6):766-767. doi: 10.1038/s41588-021-00826-x.
Kelley KW, Pașca SP.
Nature Genetics. 2021 Jun;53(6):766-767. doi: 10.1038/s41588-021-00826-x.
Research and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions.
Paşca SP, Veenstra-VanderWeele J, McPartland JC.
Molecular Psychiatry. 2021 May;26(5):1429-1431. doi: 10.1038/s41380-020-0830-5.
Paşca SP, Veenstra-VanderWeele J, McPartland JC.
Molecular Psychiatry. 2021 May;26(5):1429-1431. doi: 10.1038/s41380-020-0830-5.
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.
Agoglia RM, Sun D, Birey F, Yoon SJ, Miura Y, Sabatini K, Pașca SP, Fraser HB. Nature. 2021 Apr;592(7854):421-427. doi: 10.1038/s41586-021-03343-3. |
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pașca SP, Geschwind DH. Nature Neuroscience. 2021 Mar;24(3):331-342. doi: 10.1038/s41593-021-00802-y. |
2020
Generation of Functional Human 3D Cortico-Motor Assembloids.
Andersen J, Revah O, Miura Y, Thom N, Amin ND, Kelley KW, Singh M, Chen X, Thete MV, Walczak EM, Vogel H, Fan HC, Paşca SP. Cell. 2020 Dec 23;183(7):1913-1929.e26. doi: 10.1016/j.cell.2020.11.017. |
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Pașca SP. Nature Biotechnology. 2020 Dec;38(12):1421-1430. doi: 10.1038/s41587-020-00763-w. |
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, Ikeda K, Amin ND, Sakai N, Yazawa M, Kushan L, Nishino S, Porteus MH, Rapoport JL, Bernstein JA, O'Hara R, Bearden CE, Hallmayer JF, Huguenard JR, Geschwind DH, Dolmetsch RE, Paşca SP. Nature Medicine. 2020 Dec;26(12):1888-1898. doi: 10.1038/s41591-020-1043-9. |
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals.
Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang H, Fenno LE, Tok JB, Pașca SP, Shen K, Bao Z, Deisseroth K.
Science. 2020 Mar 20;367(6484):1372-1376. doi: 10.1126/science.aay4866.
Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang H, Fenno LE, Tok JB, Pașca SP, Shen K, Bao Z, Deisseroth K.
Science. 2020 Mar 20;367(6484):1372-1376. doi: 10.1126/science.aay4866.
Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease.
Marton RM, Pașca SP. Trends in Cell Biology. 2020 Feb;30(2):133-143. doi: 10.1016/j.tcb.2019.11.004. |
Chromatin accessibility dynamics in a model of human forebrain development.
Trevino AE, Sinnott-Armstrong N, Andersen J, Yoon SJ, Huber N, Pritchard JK, Chang HY, Greenleaf WJ, Pașca SP. Science. 2020 Jan 24;367(6476):eaay1645. doi: 10.1126/science.aay1645. |
2019
Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome.
Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, Paşca SP, Palmer TD, Dolmetsch RE.
Elife. 2019 Dec 23;8:e51037. doi: 10.7554/eLife.51037.
Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, Paşca SP, Palmer TD, Dolmetsch RE.
Elife. 2019 Dec 23;8:e51037. doi: 10.7554/eLife.51037.
The hidden biology of the human brain.
Pașca SP.
Nature Medicine. 2019 Nov;25(11):1655. doi: 10.1038/s41591-019-0621-1.
Pașca SP.
Nature Medicine. 2019 Nov;25(11):1655. doi: 10.1038/s41591-019-0621-1.
Engineering a Genetically Encoded Magnetic Protein Crystal.
Li TL, Wang Z, You H, Ong Q, Varanasi VJ, Dong M, Lu B, Paşca SP, Cui B.
Nano Letters. 2019 Oct 9;19(10):6955-6963. doi: 10.1021/acs.nanolett.9b02266.
Li TL, Wang Z, You H, Ong Q, Varanasi VJ, Dong M, Lu B, Paşca SP, Cui B.
Nano Letters. 2019 Oct 9;19(10):6955-6963. doi: 10.1021/acs.nanolett.9b02266.
A framework for the investigation of rare genetic disorders in neuropsychiatry.
Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, Glahn DC, Goldstein DB, Ledbetter DH, Mulle JG, Pasca SP, Samaco R, Sebat J, Pariser A, Lehner T, Gur RE, Bearden CE.
Nature Medicine. 2019 Oct;25(10):1477-1487. doi: 10.1038/s41591-019-0581-5.
Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, Glahn DC, Goldstein DB, Ledbetter DH, Mulle JG, Pasca SP, Samaco R, Sebat J, Pariser A, Lehner T, Gur RE, Bearden CE.
Nature Medicine. 2019 Oct;25(10):1477-1487. doi: 10.1038/s41591-019-0581-5.
Engineered materials for organoid systems.
Kratochvil MJ, Seymour AJ, Li TL, Paşca SP, Kuo CJ, Heilshorn SC.
Nature Reviews Materials. 2019 Sep;4(9):606-622. doi: 10.1038/s41578-019-0129-9.
Kratochvil MJ, Seymour AJ, Li TL, Paşca SP, Kuo CJ, Heilshorn SC.
Nature Reviews Materials. 2019 Sep;4(9):606-622. doi: 10.1038/s41578-019-0129-9.
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M.
Neuron. 2019 Jul 17;103(2):250-265.e8. doi: 10.1016/j.neuron.2019.04.032.
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M.
Neuron. 2019 Jul 17;103(2):250-265.e8. doi: 10.1016/j.neuron.2019.04.032.
Human 3D cellular model of hypoxic brain injury of prematurity.
Pașca AM, Park JY, Shin HW, Qi Q, Revah O, Krasnoff R, O'Hara R, Willsey AJ, Palmer TD, Pașca SP. Nature Medicine. 2019 May;25(5):784-791. doi: 10.1038/s41591-019-0436-0. |
Cell diversity in the human cerebral cortex: from the embryo to brain organoids.
Arlotta P, Paşca SP.
Current Opinion in Neurobiology. 2019 Jun;56:194-198. doi: 10.1016/j.conb.2019.03.001.
Arlotta P, Paşca SP.
Current Opinion in Neurobiology. 2019 Jun;56:194-198. doi: 10.1016/j.conb.2019.03.001.
Polarizing brain organoids.
Miura Y, Pașca SP.
Nature Biotechnology. 2019 Apr;37(4):377-378. doi: 10.1038/s41587-019-0084-4.
Miura Y, Pașca SP.
Nature Biotechnology. 2019 Apr;37(4):377-378. doi: 10.1038/s41587-019-0084-4.
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures.
Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR, Pașca SP. Nature Neuroscience. 2019 Mar;22(3):484-491. doi: 10.1038/s41593-018-0316-9. |
Reliability of human cortical organoid generation.
Yoon SJ, Elahi LS, Pașca AM, Marton RM, Gordon A, Revah O, Miura Y, Walczak EM, Holdgate GM, Fan HC, Huguenard JR, Geschwind DH, Pașca SP. Nature Methods. 2019 Jan;16(1):75-78. doi: 10.1038/s41592-018-0255-0. |
Assembling human brain organoids.
Paşca SP. Science. 2019 Jan 11;363(6423):126-127. doi: 10.1126/science.aau5729. |
2018
Absent forebrain replaced by embryonic stem cells.
Andersen J, Pașca SP.
Nature. 2018 Nov;563(7729):44-45. doi: 10.1038/d41586-018-06933-w.
Andersen J, Pașca SP.
Nature. 2018 Nov;563(7729):44-45. doi: 10.1038/d41586-018-06933-w.
Building Models of Brain Disorders with Three-Dimensional Organoids.
Amin ND, Paşca SP. Neuron. 2018 Oct 24;100(2):389-405. doi: 10.1016/j.neuron.2018.10.007. |
Generation and assembly of human brain region-specific three-dimensional cultures.
Sloan SA, Andersen J, Pașca AM, Birey F, Pașca SP. Nature Protocols. 2018 Sep;13(9):2062-2085. doi: 10.1038/s41596-018-0032-7. |
The ethics of experimenting with human brain tissue.
Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H.
Nature. 2018 Apr;556(7702):429-432. doi: 10.1038/d41586-018-04813-x.
Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H.
Nature. 2018 Apr;556(7702):429-432. doi: 10.1038/d41586-018-04813-x.
Building three-dimensional human brain organoids.
Paşca SP.
Nature Neuroscience. 2018 Mar 28. doi: 10.1038/s41593-018-0107-3.
Paşca SP.
Nature Neuroscience. 2018 Mar 28. doi: 10.1038/s41593-018-0107-3.
A human cellular model of amyotrophic lateral sclerosis.
Marton RM, Paşca SP.
Nature Medicine. 2018 Mar 6;24(3):256-257. doi: 10.1038/nm.4509.
Marton RM, Paşca SP.
Nature Medicine. 2018 Mar 6;24(3):256-257. doi: 10.1038/nm.4509.
The rise of three-dimensional human brain cultures.
Pașca SP. Nature. 2018 Jan 24;553(7689):437-445. doi: 10.1038/nature25032. |
2017
The Zika threat to the periphery.
Khan TA, Paşca SP.
Nature Neuroscience. 2017 Aug 29;20(9):1191-1192. doi: 10.1038/nn.4633.
Khan TA, Paşca SP.
Nature Neuroscience. 2017 Aug 29;20(9):1191-1192. doi: 10.1038/nn.4633.
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP. Neuron. 2017 Aug 16;95(4):779-790.e6. doi: 10.1016/j.neuron.2017.07.035. |
MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis.
Madelaine R, Sloan SA, Huber N, Notwell JH, Leung LC, Skariah G, Halluin C, Paşca SP, Bejerano G, Krasnow MA, Barres BA, Mourrain P.
Cell Reports. 2017 Aug 15;20(7):1533-1542. doi: 10.1016/j.celrep.2017.07.051.
Madelaine R, Sloan SA, Huber N, Notwell JH, Leung LC, Skariah G, Halluin C, Paşca SP, Bejerano G, Krasnow MA, Barres BA, Mourrain P.
Cell Reports. 2017 Aug 15;20(7):1533-1542. doi: 10.1016/j.celrep.2017.07.051.
Assembly of functionally integrated human forebrain spheroids.
Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Paşca SP. Nature. 2017 May 4;545(7652):54-59. doi: 10.1038/nature22330. |
Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring.
Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA.
PNAS. 2017 Mar 7;114(10):E1866-E1874. doi: 10.1073/pnas.1615375114.
Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA.
PNAS. 2017 Mar 7;114(10):E1866-E1874. doi: 10.1073/pnas.1615375114.
2016
Neural Differentiation in the Third Dimension: Generating a Human Midbrain.
Marton RM, Paşca SP.
Cell Stem Cell. 2016 Aug 4;19(2):145-146. doi: 10.1016/j.stem.2016.07.017.
Marton RM, Paşca SP.
Cell Stem Cell. 2016 Aug 4;19(2):145-146. doi: 10.1016/j.stem.2016.07.017.
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.
Sun Y, Paşca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE.
Elife. 2016 Jul 26;5:e13073. doi: 10.7554/eLife.13073.
Sun Y, Paşca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE.
Elife. 2016 Jul 26;5:e13073. doi: 10.7554/eLife.13073.
Personalized Human Cortical Spheroids.
Paşca SP.
The American Journal of Psychiatry. 2016 Apr 1;173(4):332-3. doi: 10.1176/appi.ajp.2016.16020133.
Paşca SP.
The American Journal of Psychiatry. 2016 Apr 1;173(4):332-3. doi: 10.1176/appi.ajp.2016.16020133.
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.
Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V.
Nature Biotechnology. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440.
Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V.
Nature Biotechnology. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440.
2014-2015
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, Paşca SP. Nature Methods. 2015 Jul;12(7):671-8. doi: 10.1038/nmeth.3415. |
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.
Tian Y, Voineagu I, Paşca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH.
Genome Medicine. 2014 Oct 10;6(10):75. doi: 10.1186/s13073-014-0075-5.
Tian Y, Voineagu I, Paşca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH.
Genome Medicine. 2014 Oct 10;6(10):75. doi: 10.1186/s13073-014-0075-5.
Generating human neurons in vitro and using them to understand neuropsychiatric disease.
Paşca SP, Panagiotakos G, Dolmetsch RE.
Annual Reviews Neuroscience. 2014;37:479-501. doi: 10.1146/annurev-neuro-062012-170328.
Paşca SP, Panagiotakos G, Dolmetsch RE.
Annual Reviews Neuroscience. 2014;37:479-501. doi: 10.1146/annurev-neuro-062012-170328.