Publications

Preprints

Assembloid model to study loop circuits of the human nervous system
Yuki Miura, Ji-il Kim, Ovidiu Jurjuț, Kevin W. Kelley, Xiao Yang, Xiaoyu Chen, Mayuri Vijay Thete, Omer Revah, Bianxiao Cui, Marius Pachitariu, Sergiu P Pașca
bioRxiv 2024 Oct 14. doi: 10.1101/2024.10.13.617729
Midline Assembloids Reveal Regulators of Human Axon Guidance
Massimo M. Onesto, Neal D. Amin, Chenjie Pan, Xiaoyu Chen, Noah Reis, Alfredo M. Valencia, Zuzana Hudacova, James P. McQueen, Marc Tessier-Lavigne, Sergiu P. Paşca
bioRxiv 2024 June 26. doi: 10.1101/2024.06.26.600229
Developmental convergence and divergence in human stem cell models of autism spectrum disorder
Aaron Gordon, Se-Jin Yoon, Lucy K Bicks, Jaqueline M Martin, Greta Pintacuda, Stephanie Arteaga, Brie Wamsley, Qiuyu Guo, Lubayna Elahi, Ricardo E. Dolmetsch, Jonathan A Bernstein, Ruth O’Hara, Joachim F Hallmayer, Kasper Lage, Sergiu P Pasca, Daniel H Geschwind
bioRxiv 2024 April 2. doi: 10.1101/2024.04.01.587492
Human assembloid model of the ascending neural sensory pathway
Ji-il Kim, Kent Imaizumi, Mayuri Vijay Thete, Zuzana Hudacova, Ovidiu Jurjuţ, Neal D. Amin, Grégory Scherrer, Sergiu P. Paşca
bioRxiv 2024 March 12. doi: 10.1101/2024.03.11.584539
An integrated transcriptomic cell atlas of human neural organoids
Zhisong He, Leander Dony, Jonas Simon Fleck, Artur Szałata, Katelyn X. Li, Irena Slišković, Hsiu-Chuan Lin, Malgorzata Santel, Alexander Atamian, Giorgia Quadrato, Jieran Sun, Sergiu P. Paşca, J. Gray Camp, Fabian Theis, Barbara Treutlein
bioRxiv 2023 October 6. doi: 10.1101/2023.10.05.561097
Biocompatible polymers for scalable production of human neural organoids
Genta Narazaki, Yuki Miura, Sergey D. Pavlov, Mayuri Vijay Thete, Julien G. Roth, Sungchul Shin, Sarah C. Heilshorn, Sergiu P. Pașca
bioRxiv 2022 May 17. doi: 10.1101/2022.03.18.484949
Landscape of human spinal cord cell type diversity at midgestation
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Neal D. Amin, Se-Jin Yoon, William J. Greenleaf, Fabian Müller,  Anca M. Pașca, Julia A. Kaltschmidt, Sergiu Pașca
bioRxiv 2021 Dec 29. doi: 10.1101/2021.12.29.473693

Peer-reviewed papers

2024

Generating human neural diversity with a multiplexed morphogen screen in organoids
Neal D. Amin, Kevin W. Kelley, Konstantin Kaganovsky, Massimo Onesto, Jin Hao, Yuki Miura, James P. McQueen, Noah Reis, Genta Narazaki, Tommy Li, Shravanti Kulkarni, Sergey Pavlov, Sergiu P. Pașca
Cell Stem Cell. 2024 Dec 5; Volume 31, Issue 12, P1831-1846.e9. doi:10.1016/j.stem.2024.10.016. Preprint: bioRxiv
Assembloid models of cell-cell interaction to study tissue and disease biology
Massimo M. Onesto, Ji-il Kim, Sergiu P. Paşca
Cell Stem Cell. 2024 Oct 24; S1934-5909(24)00360-6. doi: 10.1016/j.stem.2024.09.017
Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway
Ji-il Kim, Yuki Miura, Min-Yin Li, Omer Revah, Sridhar Selvaraj, Fikri Birey, Xiangling Meng, Mayuri Vijay Thete, Sergey D. Pavlov, Jimena Andersen, Anca M. Paşca, Matthew H. Porteus, John R. Huguenard, Sergiu P. Paşca
Neuron. 2024 Oct 16; S0896-6273(24)00692-5. doi:10.1016/j.neuron.2024.09.020. Preprint: bioRxiv
Host circuit engagement of human cortical organoids transplanted in rodents
Kevin W. Kelley, Omer Revah, Felicity Gore, Konstantin Kaganovsky, Xiaoyu Chen, Karl Deisseroth, Sergiu P Pașca
Nature Protocols. 2024 Jul 29. doi: 10.1038/s41596-024-01029-4
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Xiaoyu Chen, Fikri Birey, Min-Yin Li, Omer Revah, Rebecca Levy, Mayuri Vijay Thete, Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard, Sergiu P. Pașca
Nature. 2024 Apr; 628(8009):818-825. doi: 10.1038/s41586-024-07310-6
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids
Xiao Yang, Csaba Forró, Thomas L. Li, Yuki Miura, Tomasz J. Zaluska, Ching-Ting Tsai, Sabina Kanton, James P. McQueen, Xiaoyu Chen, Valentina Mollo, Francesca Santoro, Sergiu P. Pașca, Bianxiao Cui
Nature Biotechnology. 2024 Jan 22. doi: 10.1038/s41587-023-02081-3
Constructing human neural circuits in living systems by transplantation
Sergiu P. Paşca
Cell. 2024 Jan 4;187(1):8-13. doi: 10.1016/j.cell.2023.12.008

2023

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos, Michael C. Bassik, and Sergiu P. Pașca*
Nature. 2023 Oct; 622(7982):359-366. doi: 10.1038/s41586-023-06564-w
bioRxiv 2022 Sept 6. doi: 10.1101/2022.09.06.506845
Roadmap for developing biologically inspired therapeutics for genetic brain disorders
Kent Imaizumi & Sergiu P. Paşca*
Trends in Molecular Medicine. 2023 August 14; S1471-4914(23)00155-7. doi: 10.1016/j.molmed.2023.07.005
Spatially controlled construction of assembloids using bioprinting
Julien G. Roth, Lucia G. Brunel, Michelle S. Huang, Yueming Liu, Betty Cai, Sauradeep Sinha, Fan Yang, Sergiu P. Pașca, Sungchul Shin, Sarah C. Heilshorn
Nature Communications. 2023 July 19; 14(1):4346. doi: 10.1038/s41467-023-40006-5
Single-cell transcriptomic landscape of the developing human spinal cord
Jimena Andersen, Nicholas Thom, Jennifer L. Shadrach, Xiaoyu Chen, Massimo Mario Onesto, Neal D. Amin, Se-Jin Yoon, Li Li, William J. Greenleaf, Fabian Müller, Anca M. Pașca, Julia A. Kaltschmidt, Sergiu P. Pașca*
Nature Neuroscience. 2023 May; 26(5):902-914. doi: 10.1038/s41593-023-01311-w
What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders?
Rebecca J. Levy & Sergiu P. Paşca*
Biological Psychiatry. 2023 Apr 1; 93(7):632-641. doi: 10.1016/j.biopsych.2022.11.017
A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder 
Rebecca J. Levy, Katherine W. Timothy, Jack F. G. Underwood, Jeremy Hall, Jonathan A. Bernstein*, Sergiu P. Paşca*
Pediatric Neurology. 2023 Jan; 138:101-106. doi: 10.1016/j.pediatrneurol.2022.10.013
medRxiv

2022

Stretchable mesh microelectronics for the biointegration and stimulation of human neural organoids
Thomas L. Li, Yuxin Liu, Csaba Forro, Xiao Yang, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P. Pașca*
Biomaterials. 2022 Nov; 290:121825. doi: 10.1016/j.biomaterials.2022.121825
Free PMC article
Human assembloids
Sabina Kanton & Sergiu P. Paşca*
Development. 2022 Oct 15; 149(20):dev201120. doi: 10.1242/dev.201120
How collaboration between bioethicists and neuroscientists can advance research
Insoo Hyun, J. C. Scharf-Deering, Sarah Sullivan, John Dennis Aach, Paola Arlotta, Matthew L. Baum, George M. Church, Aaron Goldenberg, Henry T. Greely, Parastoo Khoshakhlagh, Richie E. Kohman, Melissa Lopes, Caroline Lowenthal, Aric Lu, Alex H. M. Ng, Sergiu P. Pasca, Bruna Paulsen, Martina Pigoni, Christopher T. Scott, David A. Silbersweig, Mark A. Skylar-Scott, Robert D. Truog, Jeantine E. Lunshof
Nature Neuroscience. 2022 Nov; 25(11):1399-1401. doi: 10.1038/s41593-022-01187-2
Maturation and circuit integration of transplanted human cortical organoids
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth & Sergiu P. Pașca*
Nature. 2022 Oct 13; 610:319–326. doi: 10.1038/s41586-022-05277-w
Mouse embryo models built from stem cells take shape in a dish
Neal D Amin, Sergiu P Pașca*
Nature. 2022 Oct 3; 610:39–40. doi: 10.1038/d41586-022-03075-y
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
Thomas L. Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P. Paşca*
Biomaterials. 2022 Sept 30. doi: 10.1101/2022.06.10.495715
BioRxiv
Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model
Ren Song, Katja Pekrun, Themasap A. Khan, Feijie Zhang, Sergiu P. Paşca, Mark A. Kay
Molecular Therapy Methods & Clinical Development. 2022 Dec 8; Vol 27:73–88. doi: 10.1016/j.omtm.2022.09.002
A nomenclature consensus for nervous system organoids and assembloids
Sergiu P. Pașca*, Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, Arnold R. Kriegstein, Madeline A. Lancaster, Guo-Li Ming, Alysson R. Muotri, In-Hyun Park, Orly Reiner, Hongjun Song, Lorenz Studer, Sally Temple, Giuseppe Testa, Barbara Treutlein, Flora M. Vaccarino ​
Nature. 2022 Sept 29; 609:907–910. doi: 10.1038/s41586-022-05219-6
Imaging neuronal migration and network activity in human forebrain assembloids
Fikri Birey and Sergiu P. Pașca*
STAR Protocols. 2022 Jun 17. doi: 10.1016/j.xpro.2022.101478
A tissue-like neurotransmitter sensor for the brain and gut
Jinxing Li, Yuxin Liu, Lei Yuan, Baibing Zhang, Estelle Spear Bishop, Kecheng Wang, Jing Tang, Yu-Qing Zheng, Wenhui Xu, Simiao Niu, Levent Beker, Thomas L Li, Gan Chen, Modupeola Diyaolu, Anne-Laure Thomas, Vittorio Mottini, Jeffrey B-H Tok, James C Y Dunn, Bianxiao Cui, Sergiu P Pașca, Yi Cui, Aida Habtezion, Xiaoke Chen, Zhenan Bao
Nature. 2022 Jun; 606(7912):94-101. doi: 10.1038/s41586-022-04615-2
Free PMC article
Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.
Birey F, Li MY, Gordon A, Thete MV, Valencia AM, Revah O, Paşca AM, Geschwind DH, and Sergiu P. Pașca*.
Cell Stem Cell. 2022 Feb 3; 29(2):248-264.e7. doi: 10.1016/j.stem.2021.11.011
BioRxiv 
Chromatin dynamics in human brain development and disease.
Valencia AM, Sergiu P. Pașca*
Trends in Cell Biology. 2022 Feb; 32(2):98-101. doi: 10.1016/j.tcb.2021.09.001
Engineering brain assembloids to interrogate human neural circuits.
Yuki Miura, Min-Yin Li, Omer Revah, Se-Jin Yoon, Genta Narazaki, and PSergiu P. Pașca*
Nature Protocols. 2022 Jan; 17(1):15-35. doi: 10.1038/s41596-021-00632-z
A matter of space and time: Emerging roles of disease-associated proteins in neural development.
Georgia Panagiotakos*, Sergiu P. Pașca*
Neuron. 2022 Jan 19; 110(2):195-208. doi: 10.1016/j.neuron.2021.10.035
Human brain organogenesis: Toward a cellular understanding of development and disease.
Kevin W. Kelley, Sergiu P. Pașca*
Cell. 2022 Jan 6;185(1):42-61. doi: 10.1016/j.cell.2021.10.003

2021

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.
Science Translational Medicine. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919.
Nanotechnology Enables Novel Modalities for Neuromodulation.
Yang X, McGlynn E, Das R, Paşca SP, Cui B, Heidari H.
Advanced Materials. 2021 Dec;33(52):e2103208. doi: 10.1002/adma.202103208.
Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.
Trevino AE, Müller F, Andersen J, Sundaram L, Kathiria A, Shcherbina A, Farh K, Chang HY, Pașca AM, Kundaje A, Sergiu P. Pașca*, Greenleaf WJ*
Cell. 2021 Sep 16;184(19):5053-5069.e23. doi: 10.1016/j.cell.2021.07.039.
BioRxiv
Advancing models of neural development with biomaterials.
Roth JG, Huang MS, Li TL, Feig VR, Jiang Y, Cui B, Greely HT, Bao Z, Paşca SP, Heilshorn SC.
Nature Reviews Neuroscience. 2021 Oct;22(10):593-615. doi: 10.1038/s41583-021-00496-y.
Mapping human brain organoids on a spatial atlas.
Miura Y, Pașca SP.*
Cell Stem Cell. 2021 Jun 3;28(6):983-984. doi: 10.1016/j.stem.2021.05.004.
Scrutinizing disease states and regulation in human microglia.
Kelley KW, Pașca SP*.
Nature Genetics. 2021 Jun;53(6):766-767. doi: 10.1038/s41588-021-00826-x.
Research and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions.
Sergiu P. Pașca*, Veenstra-VanderWeele J, McPartland JC.
Molecular Psychiatry. 2021 May;26(5):1429-1431. doi: 10.1038/s41380-020-0830-5.
Primate cell fusion disentangles gene regulatory divergence in neurodevelopment.
Agoglia RM, Sun D, Birey F, Yoon SJ, Miura Y, Sabatini K, Sergiu P. Pașca*, Fraser HB*.
Nature. 2021 Apr;592(7854):421-427. doi: 10.1038/s41586-021-03343-3.
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Sergiu P. Pașca*, Geschwind DH*.
Nature Neuroscience. 2021 Mar;24(3):331-342. doi: 10.1038/s41593-021-00802-y.

2020

Generation of Functional Human 3D Cortico-Motor Assembloids.
Andersen J, Revah O, Miura Y, Thom N, Amin ND, Kelley KW, Singh M, Chen X, Thete MV, Walczak EM, Vogel H, Fan HC, and Sergiu P. Pașca*
Cell. 2020 Dec 23;183(7):1913-1929.e26. doi: 10.1016/j.cell.2020.11.017.
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.
Miura Y, Li MY, Birey F, Ikeda K, Revah O, Thete MV, Park JY, Puno A, Lee SH, Porteus MH, Sergiu P. Pașca*.
Nature Biotechnology. 2020 Dec;38(12):1421-1430. doi: 10.1038/s41587-020-00763-w.
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.
Khan TA, Revah O, Gordon A, Yoon SJ, Krawisz AK, Goold C, Sun Y, Kim CH, Tian Y, Li MY, Schaepe JM, Ikeda K, Amin ND, Sakai N, Yazawa M, Kushan L, Nishino S, Porteus MH, Rapoport JL, Bernstein JA, O'Hara R, Bearden CE, Hallmayer JF, Huguenard JR, Geschwind DH, Dolmetsch RE, and Sergiu P. Pașca*
Nature Medicine. 2020 Dec;26(12):1888-1898. doi: 10.1038/s41591-020-1043-9.
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals.
Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang H, Fenno LE, Tok JB, Pașca SP, Shen K, Bao Z, Deisseroth K.
Science. 2020 Mar 20;367(6484):1372-1376. doi: 10.1126/science.aay4866.
Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease.
Rebecca M. Marton, Sergiu P. Pașca*
Trends in Cell Biology. 2020 Feb;30(2):133-143. doi: 10.1016/j.tcb.2019.11.004.
Chromatin accessibility dynamics in a model of human forebrain development.
Trevino AE, Sinnott-Armstrong N, Andersen J, Yoon SJ, Huber N, Pritchard JK, Chang HY, Greenleaf WJ*, Sergiu P. Pașca*
Science. 2020 Jan 24;367(6476):eaay1645. doi: 10.1126/science.aay1645.

2019

Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome.
Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, Paşca SP, Palmer TD, Dolmetsch RE.
Elife. 2019 Dec 23;8:e51037. doi: 10.7554/eLife.51037.
The hidden biology of the human brain.
Pașca SP.
Nature Medicine. 2019 Nov;25(11):1655. doi: 10.1038/s41591-019-0621-1.
Engineering a Genetically Encoded Magnetic Protein Crystal.
Li TL, Wang Z, You H, Ong Q, Varanasi VJ, Dong M, Lu B, Sergiu P. Pașca*, Bianxiao Cui*.
Nano Letters. 2019 Oct 9;19(10):6955-6963. doi: 10.1021/acs.nanolett.9b02266.
A framework for the investigation of rare genetic disorders in neuropsychiatry.
Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, Glahn DC, Goldstein DB, Ledbetter DH, Mulle JG, Pasca SP, Samaco R, Sebat J, Pariser A, Lehner T, Gur RE, Bearden CE.
Nature Medicine. 2019 Oct;25(10):1477-1487. doi: 10.1038/s41591-019-0581-5.
Engineered materials for organoid systems.
Kratochvil MJ, Seymour AJ, Li TL, Paşca SP, Kuo CJ, Heilshorn SC.
Nature Reviews Materials. 2019 Sep;4(9):606-622. doi: 10.1038/s41578-019-0129-9.
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M.
Neuron. 2019 Jul 17;103(2):250-265.e8. doi: 10.1016/j.neuron.2019.04.032.
Human 3D cellular model of hypoxic brain injury of prematurity.
Pașca AM, Park JY, Shin HW, Qi Q, Revah O, Krasnoff R, O'Hara R, Willsey AJ, Palmer TD, and ​Sergiu P. Pașca*.
Nature Medicine. 2019 May;25(5):784-791. doi: 10.1038/s41591-019-0436-0.
Cell diversity in the human cerebral cortex: from the embryo to brain organoids.
Paola Arlotta*, Sergiu P. Pașca*.
Current Opinion in Neurobiology. 2019 Jun;56:194-198. doi: 10.1016/j.conb.2019.03.001.
Polarizing brain organoids.
Yuki Miura, Sergiu P. Pașca*
Nature Biotechnology. 2019 Apr;37(4):377-378. doi: 10.1038/s41587-019-0084-4.
Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures.
Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR, and Sergiu P. Pașca*.
Nature Neuroscience. 2019 Mar;22(3):484-491. doi: 10.1038/s41593-018-0316-9.
Reliability of human cortical organoid generation.
Yoon SJ, Elahi LS, Pașca AM, Marton RM, Gordon A, Revah O, Miura Y, Walczak EM, Holdgate GM, Fan HC, Huguenard JR, Geschwind DH, Sergiu P. Pașca*.
Nature Methods. 2019 Jan;16(1):75-78. doi: 10.1038/s41592-018-0255-0.
Assembling human brain organoids.
​Sergiu P. Pașca*.
Science. 2019 Jan 11;363(6423):126-127. doi: 10.1126/science.aau5729.

2018

Absent forebrain replaced by embryonic stem cells.
Jimena Andersen, Sergiu P. Pașca*.
Nature. 2018 Nov;563(7729):44-45. doi: 10.1038/d41586-018-06933-w.
Building Models of Brain Disorders with Three-Dimensional Organoids.
Neal D. Amin, Sergiu P. Pașca*.
Neuron. 2018 Oct 24;100(2):389-405. doi: 10.1016/j.neuron.2018.10.007.
Generation and assembly of human brain region-specific three-dimensional cultures.
Sloan SA, Andersen J, Pașca AM, Birey F, Pașca SP.
Nature Protocols. 2018 Sep;13(9):2062-2085. doi: 10.1038/s41596-018-0032-7.
The ethics of experimenting with human brain tissue.
Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H.
Nature. 2018 Apr;556(7702):429-432. doi: 10.1038/d41586-018-04813-x.
Building three-dimensional human brain organoids.
Sergiu P. Pașca*.
Nature Neuroscience. 2018 Mar 28. doi: 10.1038/s41593-018-0107-3.
A human cellular model of amyotrophic lateral sclerosis.
Rebecca M. Marton, Sergiu P. Pașca*.
Nature Medicine. 2018 Mar 6;24(3):256-257. doi: 10.1038/nm.4509.
The rise of three-dimensional human brain cultures.
Sergiu P. Pașca*.
Nature. 2018 Jan 24;553(7689):437-445. doi: 10.1038/nature25032.

2017

The Zika threat to the periphery.
Themasap T. Khan, Sergiu P. Pașca*
Nature Neuroscience. 2017 Aug 29;20(9):1191-1192. doi: 10.1038/nn.4633.
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Sergiu P. Pașca*.
Neuron. 2017 Aug 16;95(4):779-790.e6. doi: 10.1016/j.neuron.2017.07.035.
MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis.
Madelaine R, Sloan SA, Huber N, Notwell JH, Leung LC, Skariah G, Halluin C, Paşca SP, Bejerano G, Krasnow MA, Barres BA, Mourrain P.
Cell Reports. 2017 Aug 15;20(7):1533-1542. doi: 10.1016/j.celrep.2017.07.051.
Assembly of functionally integrated human forebrain spheroids.
Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, Fan HC, Metzler KRC, Panagiotakos G, Thom N, O'Rourke NA, Steinmetz LM, Bernstein JA, Hallmayer J, Huguenard JR, Sergiu P. Pașca*.
Nature. 2017 May 4;545(7652):54-59. doi: 10.1038/nature22330.
Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring.
Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA.
PNAS. 2017 Mar 7;114(10):E1866-E1874. doi: 10.1073/pnas.1615375114.

2016

Neural Differentiation in the Third Dimension: Generating a Human Midbrain.
Rebecca M. Marton, Sergiu P. Pașca*.
Cell Stem Cell. 2016 Aug 4;19(2):145-146. doi: 10.1016/j.stem.2016.07.017.
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.
Sun Y, Paşca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein JL, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE.
Elife. 2016 Jul 26;5:e13073. doi: 10.7554/eLife.13073.
Personalized Human Cortical Spheroids.
Sergiu P. Pașca*.
The American Journal of Psychiatry. 2016 Apr 1;173(4):332-3. doi: 10.1176/appi.ajp.2016.16020133.
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.
Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V.
Nature Biotechnology. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440.

2014-2015

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, and Sergiu P. Pașca*
Nature Methods. 2015 Jul;12(7):671-8. doi: 10.1038/nmeth.3415.
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.
Tian Y, Voineagu I, Paşca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH.
Genome Medicine. 2014 Oct 10;6(10):75. doi: 10.1186/s13073-014-0075-5.
Generating human neurons in vitro and using them to understand neuropsychiatric disease.
Paşca SP, Panagiotakos G, Dolmetsch RE.
Annual Reviews Neuroscience. 2014;37:479-501. doi: 10.1146/annurev-neuro-062012-170328.

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James H. Clark Center, Bio-X
Stanford, CA 94305, USA
Office phone: 650-497-5922

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