Paşca S.P*.
Building three-dimensional human brain organoids.
Nature Neuroscience, 2018.
doi:10.1038/s41593-018-0107-3
Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Hongjun S.
The ethics of experimenting with human brain tissue
Nature 556: 429–432, 2018.
The ethics of experimenting with human brain tissue
Nature 556: 429–432, 2018.
Marton R.M. and Paşca S.P*.
A human cellular model of amyotrophic lateral sclerosis.
Nature Medicine 24(3): 256-257, 2018
A human cellular model of amyotrophic lateral sclerosis.
Nature Medicine 24(3): 256-257, 2018
Sloan S.A., Darmanis S., Huber N., Khan T.A., Birey F., Caneda C., Reimer R., Quake S.R., Barres B.A.*, and Paşca S.P.*.
Human Astrocyte Maturation Captured in 3D Cortical Spheroids Derived from Human Pluripotent Stem Cells.
Neuron, 95: 779-790, 2017.
[Featured Article] [Preview] [NIH Press Release] [Scope]
Image: "Persistence of Astrocytes" by Mesa Schumacher
Sloan S.A., Darmanis S., Huber N., Khan T.A., Birey F., Caneda C., Reimer R., Quake S.R., Barres B.A.*, and Paşca S.P.*.
Human Astrocyte Maturation Captured in 3D Cortical Spheroids Derived from Human Pluripotent Stem Cells.
Neuron, 95: 779-790, 2017.
[Featured Article] [Preview] [NIH Press Release] [Scope]
Image: "Persistence of Astrocytes" by Mesa Schumacher
Madelaine R., Sloan S.A., Huber N., Notwell J.H., Leung L.C., Skariah G., Hulluin C., Paşca S.P., Bejerano G., Krasnow M.A., Barres B.A., Mourrain P.
MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis.
Cell Reports 20 (7), 1533-1542, 2017.
Birey F. (co-first), Andersen J. (co-first), Makinson C. (co-first), Islam S., Wei W., Huber N., Fan C.H., Metzler K., Panagiotakos G., Thom N., O’Rourke N.A., Steinmetz L.M., Bernstein J.A., Hallmayer J., Huguenard J.R., and Paşca S.P.*.
Assembly of Functionally-Integrated Forebrain Spheroids from Human Pluripotent Stem Cells to Study Development and Disease.
Nature (Article), 545: 54-59, 2017.
[Stanford Press release] [NIH Press release] [MQ] [NIH Video] [Scope Blog]
[F1000] [NIH Highlights of 2017] [NARSAD/BBRF Top Advances of 2017]
Assembly of Functionally-Integrated Forebrain Spheroids from Human Pluripotent Stem Cells to Study Development and Disease.
Nature (Article), 545: 54-59, 2017.
[Stanford Press release] [NIH Press release] [MQ] [NIH Video] [Scope Blog]
[F1000] [NIH Highlights of 2017] [NARSAD/BBRF Top Advances of 2017]
Can Y., Hjorth M., Chen H., Birey F., Leal-Ortiz S., Han C., Santiago J.G., Paşca S.P., Wu J., Melosh N.A.
Non-destructive nanostraw intracellular sampling for longitudinal cell monitoring.
Proceedings of the National Academy of Sciences, 114(10): E1866-74 (2017).
[Press release] [Cozzarelli Prize]
Marton R.M. and Paşca S.P*.
Neural differentiation in the third dimension: making a human midbrain.
Cell Stem Cells, 19(2):145-6, 2016.
Neural differentiation in the third dimension: making a human midbrain.
Cell Stem Cells, 19(2):145-6, 2016.
Sun Y., Paşca S.P., Portmann T., Goold C., Worringer K.A., Guan W., Chan K., Gai H., Vogt D., Chen Y-J.J., Mao R., Chan K., Rubenstein J., Madison D.V., Hallmayer J., Froehlich-Santino W.M., Bernstein J., and Dolmetsch R.E.
A deleterious NaV1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.
eLife, 5: e13073, 2016.
Paşca SP*.
Personalized Human Cortical Spheroids.
American Journal of Psychiatry, 173(4): 332-3, 2016.
Personalized Human Cortical Spheroids.
American Journal of Psychiatry, 173(4): 332-3, 2016.
Deverman B.E., Pravdo P.L., Simpson B.P., Kumar S.R., Chan K.Y., Banerjee A., Wu W-L., Yang B., Huber N., Paşca S.P., Gradinaru V.
Cre-dependent capsid selection yields AAVs for global gene transfer to the adult brain.
Nature Biotechnology, 34(2): 204-9, 2016 .
Paşca A.M. (co-first), Sloan S. (co-first), Clarke L.E., Tian Y., Makinson C., Huber N., Kim C-H., Park J-Y., O’Rourke N.A., Nguyen K., Smith S.J., Huguenard J., Geschwind D.H., Barres B.A., and Paşca S.P*.
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D cultures.
Nature Methods, 12: 671-678, 2015.
[Press release] [Blog][NIH Press Release] [SFARI] [F1000] [Key Advances in hiPSC Modeling]
Paşca S.P.*, Panagiotakos G., Dolmetsch R.E.
Generating human neurons in vitro and using them to understand neuropsychiatric disease.
Annual Review of Neuroscience, 37: 479-501; 2014.
Tian Y., Voineagu I., Paşca S.P., Won H., Chandran V., Horvath S., Dolmetsch R.E., Geschwind D.H.
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.
Genome Medicine, 6:75, 2014.
[Editor's pick]
Esposito G., and Paşca S.P.*
Motor abnormalities as a putative endophenotype for autism spectrum disorders.
Frontiers in Neuroscience 7: 43, 2013;
Gomez-Ospina N., Panagiotakos G., Portmann T., Paşca S.P. , Rabah D., Budzillo A., Kinet J-P., Dolmetsch R.E.
A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.
PLoS ONE 8(4): e60526, 2013.
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome.
Genome Medicine, 6:75, 2014.
[Editor's pick]
Esposito G., and Paşca S.P.*
Motor abnormalities as a putative endophenotype for autism spectrum disorders.
Frontiers in Neuroscience 7: 43, 2013;
Gomez-Ospina N., Panagiotakos G., Portmann T., Paşca S.P. , Rabah D., Budzillo A., Kinet J-P., Dolmetsch R.E.
A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT.
PLoS ONE 8(4): e60526, 2013.
Krey J.K., Paşca S.P., Shcheglovitov O., Yazawa M., Schwemberger R., Rasmusson R., Dolmetsch R.E.
Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.
Nature Neuroscience 16(12): 201-09, 2013.
[Featured in Science Translational– Editor’s Choice]
Paşca S.P., Portmann T., Yazawa M., Voineagu I., Pasca A.M., Shcheglovitov O., Cord B., Palmer T.D., Chikahisa S., Seiji N., Bernstein J.A., Hallmayer J., Geschwind D.H., and Dolmetsch R.E.
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.
Nature Medicine, 17(12): 1657-62, 2011. (Cover article)
[News & Views by Huttner & Rakic]; [Highlighted in Nature Neuroscience Reviews, Cell, JAMA]; [evaluated by F1000]; [Best 2012 Neuroscience article published at Stanford University]; [among NIMH top 10 advances of 2011] [SFARI top 10 papers of 2011] [selected for NatureOutlook Autism Collection].
Paşca S.P., Singer W, and Nikolic D.
Surround modulation of neuronal responses in V1 is as stable over time as responses to direct stimulation of receptive fields.
Cortex, 46(9): 199-203, 2010.
Paşca S.P., Dronca E., Nemes B., Kaucsár T, Endreffy E., Iftene F., Benga I., Cornean R., and Dronca M.
Paraoxonase 1 activities and polymorphisms in Autism Spectrum Disorders.
Journal of Cellular and Molecular Medicine, 14(3): 600-7, 2010.
Paşca S.P., Dronca E., Kaucsár T., Craciun E. C., Endreffy E., Ferencz B. K., Iftene F., Benga I., Cornean R., Banerjee R., and Dronca M.
One Carbon Metabolism Disturbances and the C677T MTHFR Gene Polymorphism in Children with Autism Spectrum Disorders.
Journal of Cellular and Molecular Medicine, 14(10): 4229-4238, 2009.
Paşca S.P. and Nesse R. M.
Vomiting is not an adaption for glaucoma (and Darwinian medicine is difficult).
Medical Hypotheses, 71(3): 472-3, 2008.
Dronca M., Paşca S.P., Nemes B., Vlase L., Vladutiu D.
Serum paraoxonase-1 activities and homocysteinemia in hemodialysis patients.
Clinical Chemistry and Laboratory Medicine, 46(6):880-890, 2008.
Miu A.C., Heilman R.M., Paşca S.P., Stefan C.A., Spanu F., Vasiu R., Olteanu A.I., and Miclea M.
Behavioral effects of enriched environment on adult rats with corpus callosum transection.
Behavioral Brain Research, 172(1): 134-144, 2006.
Paşca S.P., Nemes B., Vlase L., Gagyi C. E., Dronca E., Miu A. C. and Dronca M.
High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.
Life Sciences, 78(19): 2244-2248, 2006.
Miu A.C., Paşca S.P. and Miclea M.
The corpus callosum and the power of complementary paradigms in developmental cognitive neuroscience.
Cognition, Brain, Behavior, 9: 423-450, 2005.
Surround modulation of neuronal responses in V1 is as stable over time as responses to direct stimulation of receptive fields.
Cortex, 46(9): 199-203, 2010.
Paşca S.P., Dronca E., Nemes B., Kaucsár T, Endreffy E., Iftene F., Benga I., Cornean R., and Dronca M.
Paraoxonase 1 activities and polymorphisms in Autism Spectrum Disorders.
Journal of Cellular and Molecular Medicine, 14(3): 600-7, 2010.
Paşca S.P., Dronca E., Kaucsár T., Craciun E. C., Endreffy E., Ferencz B. K., Iftene F., Benga I., Cornean R., Banerjee R., and Dronca M.
One Carbon Metabolism Disturbances and the C677T MTHFR Gene Polymorphism in Children with Autism Spectrum Disorders.
Journal of Cellular and Molecular Medicine, 14(10): 4229-4238, 2009.
Paşca S.P. and Nesse R. M.
Vomiting is not an adaption for glaucoma (and Darwinian medicine is difficult).
Medical Hypotheses, 71(3): 472-3, 2008.
Dronca M., Paşca S.P., Nemes B., Vlase L., Vladutiu D.
Serum paraoxonase-1 activities and homocysteinemia in hemodialysis patients.
Clinical Chemistry and Laboratory Medicine, 46(6):880-890, 2008.
Miu A.C., Heilman R.M., Paşca S.P., Stefan C.A., Spanu F., Vasiu R., Olteanu A.I., and Miclea M.
Behavioral effects of enriched environment on adult rats with corpus callosum transection.
Behavioral Brain Research, 172(1): 134-144, 2006.
Paşca S.P., Nemes B., Vlase L., Gagyi C. E., Dronca E., Miu A. C. and Dronca M.
High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism.
Life Sciences, 78(19): 2244-2248, 2006.
Miu A.C., Paşca S.P. and Miclea M.
The corpus callosum and the power of complementary paradigms in developmental cognitive neuroscience.
Cognition, Brain, Behavior, 9: 423-450, 2005.
